Primary hyperaldosteronism with type V Bartter syndrome

Abstract

Primary hyperaldosteronism (PHA) is one of the main causes of endocrine hypertension (HTN). Excessive aldosterone is associated with hypokalemia, metabolic alkalosis and predominantly nocturnal polyuria. Very few cases reported around the world are related to primary hyperaldosteronism without hypertension. Type V Bartter syndrome is a rare autosomal dominant disorder characterized by increased calcium-sensitive receptor function, which causes metabolic alkalosis, hypokalemia, and elevated natriuresis with stable blood pressure levels. We present the case of a 61-year-old woman with primary hyperaldosteronism and type V Bartter syndrome confirmed by biochemical, imaging and anatomy and pathology results.